Aspirin and Salicylate

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Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis

Background: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). Objective: To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. Methods: A cross sectional multicenter study was d...

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Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis.

BACKGROUND A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). OBJECTIVE To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. METHODS A cross sectional multicenter study was done...

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Aspirin and salicylate: An old remedy with a new twist.

Salicylic acid was identified in willow bark extracts as an active anti-inflammatory compound over a century ago. Because of its bitter taste, chemical derivatives of salicylic acid (2-hydroxybenzoic acid) were synthesized and tested. Acetylsalicylic acid (aspirin) eliminated the bitter taste but retained the anti-inflammatory action, and it was introduced for treating human maladies .100 years...

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Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition.

Aspirin inhibits cyclooxygenase, thus preventing thromboxane A2 production in blood platelets and prostacyclin in vascular cells. Aspirin is rapidly hydrolyzed to salicylate in the circulation. The objectives of this study were (a) to evaluate whether administration of salicylate, though ineffective by itself, prevents the inhibitory effect of aspirin on platelet and/or vascular cyclooxygenase ...

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Salicylate-induced pulmonary edema: a complication of chronic aspirin therapy.

Case Report A 36-year-old man who smoked three packs of cigarettes per day and habitually smoked varying amounts of marijuana experienced the onset of insomnia and persistent headaches when he abruptly discontinued clomipramine therapy. He medicated his headache according to his own "usual" treatment protocol: three to four aspirin tablets as one dose, then an increased amount with each success...

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ژورنال

عنوان ژورنال: Circulation

سال: 2000

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.102.17.2022